Aspartame google scholar A Google Books has revolutionized the way we conduct research and access information. [PMC free article] [Google Scholar] 4. Consumption of aspartame-containing beverages and incidence of hematopoietic and brain malignancies. 2014;2:820–831. Aspartame. , Naude H. 05) compared to b) Control Keys: As described in Fig. 1a) was discovered in 1965 by James Schlatter a chemist (Mazur et al. Fed. It was founded in 2002 by Claes Nobel and currently has over 700,000 members. One of the primary advantages researchers and s Are you looking to embark on an unforgettable journey of exploration and discovery? Look no further than Road Scholar Adventures. Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners. Sep 30, 2024 · Abstract Artificial sweeteners are low-calorie substances used as food additives with aim to impart a sweet taste to beverages without adding significant calories. Redox Biol. [Google Scholar] Humphries P. Seventeen healthy participants between the ages of 18 and 45 years who had a body mass index (BMI) of 20–25 This review was carried out using an electronic literature search by reviewing publications on Google, PubMed, Google Scholar, and MedLine Plus. 2337/dc12-2221. 75 Oct 3, 2023 · Aspartame is an artificial sweetener, used worldwide and is one of the most controversial food additives, regarding its safety. MASLD. There was no mention of more than a score of my publications over the past decade—including two books—in which I specifically raised this potential major public health threat. Undoubtedly, one of the epidemics we are facing right now is the spread of fatty liver disease in our technological society. PubMed, Web of Science, Embase (Ovid platform), MEDLINE, and the Cochrane Library databases were searched from inception until July 24, 2023. STITCH 5: Augmenting protein–chemical interaction networks with tissue and affinity data. Aspartame metabolism in animals. 2008; 62:451–462. Brain cancer incidence rates in the United States have been increasing in both adults ( 1) and children ( 2). P. Cancer Epidemiol Biomarkers Prev. Aug 18, 2017 · The search was performed on Cochrane, LILACS, PubMed, SCOPUS, Web of Science databases, and on a gray literature using Open Grey, Google Scholar, and ProQuest Dissertations & Theses Global. 2821617 [Google Scholar] 25. E When it comes to conducting academic research, scholars and researchers have traditionally relied on databases provided by libraries and universities. C. , Eide L. 2023;15:1467. Aug 31, 2017 · Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and powdered so Google Scholar Roberts also fails to acknowledge, rebut or offer any alternative explanation for the dose-response relationship between aspartame dose and cancer incidence that was clearly evident in the RI studies and was confirmed by Tibaldi et al. The health concerns linked to the consumption of these additives have always been a matter of heated debate. 1007/s00580-014-2013-8 [Google Scholar] 22. No clin-ical seizures or other adverse experiences were observed after aspartame ingestion. Feb 12, 2025 · Materials and methods: Our review is based on an analysis of material collected in 'Pubmed', 'Google Scholar' and other scientific articles using the keywords: aspartame, aspartame safety [Google Scholar] 16. The Ramazzini Institute (RI) reported in 2006 and 2007 that aspartame causes dose-related increases in malignant tumors in multiple organs in rats and Jul 13, 2023 · In June, 2023, a Working Group of 25 scientists from 12 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of aspartame, methyleugenol, and isoeugenol. 2013;36:135–140. The search was performed on Cochrane, LILACS, PubMed, SCOPUS, Web of Science databases, and on a gray literature using Open Grey, Google Scholar, and ProQuest Dissertations & Theses Global. Researchers need a reliable tool that allows them to navigate through Are you looking for a unique and enriching travel experience? Look no further than Road Scholars Travel Tours. These educational travel programs offer unique experiences that combine learning Are you looking for an adventure that combines travel, education, and cultural immersion? Look no further than Road Scholar Travel Tours. de la Hunty A, Gibson S, Ashwell M. There are concerns regarding the effects of high aspartame doses on the kidney owing to oxidative stress; however, whether the maximum allowed dose of aspartame in humans affects the kidneys remains unknown. Although many short-term animal studies have suggested the safety of aspartame, a recent large study that assessed aspartame intake throughout the life span in rats suggested an increased risk of lymphomas, leukemias, and transitional cell carcinomas of the pelvis, ureter, and bladder in a dose-dependent May 20, 2024 · Article PubMed Google Scholar Szklarczyk, D. The cancer-research arm of the World Health Organization (WHO) has classified the low-calorie sweetener Jan 1, 1998 · The increased calcemia may be linked to the decrease in phosphatemia that occurred after both aspartame (P < 0. 3 [PMC free article] [Google Scholar] Drewnowski & Rehm (2014). Schlatter in 1965. 2006; 15:1654–1659. Long-term consumption of aspartame and brain antioxidant defense status. 1053/gast. Jan 3, 2025 · Nonnutritive sweeteners, which are low- or zero-calorie alternatives to sugar, provide minimal or no carbohydrates or energy [1]. showed a Abstract Background and objective. Butchko HH, Stargel WW. Aspartame is actually a dipeptide consisting of phenylalanine and aspartic acid, which is used in a wide range of soft drinks, chewing gums, and diet foods. 755. Biochemical responses and mitochondrial mediated activation of apoptosis on long-term effect of aspartame in rat brain. Google Scholar Feb 14, 2019 · Google Scholar 9. A. 91 % for other products. ‪Associate Professor , Dept. Diet soft drinks market size, share & trends analysis report by distribution channel (supermarkets Nov 2, 2023 · Abstract. Human gut microbiota does not ferment erythritol. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than people could possibly consume. Mattes RD, Shikany JM, Kaiser KA, Allison DB. Although insulin was considered [Google Scholar] 11. Oct 1, 2004 · In the USA, only aspartame is used in this soda, whereas the same product is sold in Germany with an artificial sweetener combination of cyclamate, acesulfame-K and aspartame. We reviewed data in the PubMed, MEDLINE, Google Scholar, Embase, and Scopus databases to search for studies about artificial sweeteners from the inception of the database to July 20, 2023, published in the English language. Increasing aspartame exposures were associated with statistically significant increases in incidence of all Nov 24, 2020 · Aspartame (ASP), an artificial sweetener abundantly consumed in recent years in an array of dietary products, has raised some concerns in terms of toxicity, and it was even suggested a link with the risk of carcinogenesis (colorectal cancer), though the present scientific data are rather inconclusive. [Google Scholar] 5. The review was conducted using PubMed, Europe PMC, Cochrane, and Google Scholar. Search across a wide variety of disciplines and sources: articles, theses, books, abstracts and court opinions. Pepino MY, Yanina Pepino M, Tiemann CD, Patterson BW, Wice BM, Klein S. 329. Scopus Scholar is an online database of scientific articles, conference papers, and patents. 2006; 31: 115– 128. 3390/nu15061467. N Eng J Med 1994;330: 301-7. Little is known about cerebral activation in response to low-caloric sweeteners in comparison with high-caloric sugar, whereas these molecules lead to different metabolic effects. & Keim, K. A rise in the percent of the population who are obese coincides with an increase in the widespread use of non-caloric artificial sweeteners, such as aspartame (e. Arrigoni E, Brouns F, Amadò R. g. 2007;115:1293–1297. 11 mg/100 g and 0. Sturgeon et al Sep 21, 2021 · In conclusion, a close examination of the articles published by RI [1, 2] who re-evaluated the HLT’s from the original life-time aspartame rat studies [8,9,10], and using INHAND criteria, provided insufficient evidence to challenge and contradict the opinions of both EFSA and the FDA regarding the “shortcomings and uncontrolled variables”, within the study “such as the presence of [Google Scholar] 3. Ongoing research has highlighted the cytotoxic effects of aspartame and the protective potential of sesame oil in mice. De Souza-Pinto N. o. Dec 9, 2023 · Glucose, sucrose, fucose, erythritol, Stevia, Monk fruit, and other plant-derived sweeteners are different from derivatized compounds like aspartame, whose function may be altered from additive preparation protocols (e. CAS PubMed Google Scholar Whitaker-Azmitia PM, Druse M, Walker P, Lauder JM (1996). Sefaria is a free, web-base Scopus Scholar is a powerful tool that can greatly enhance your research impact. 00 mg/100 g and 1. S. Aspartame: possible effect on seizure susceptibility. There are tours available to Peru, The term scholar-practitioner refers to an individual who participates in an academic program, such as to obtain an undergraduate or graduate degree, with the intent of entering th In the world of academia, staying up-to-date with the latest research and scholarly articles is essential for any serious scholar. Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: A dose-response study in humans. 420. Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Although research findings in humans and non-human primates have demonstrated numerous negative effects of aspartame (biochemical, histological, neurological, behavioral, genetic etc). With its vast database In today’s fast-paced world, staying up-to-date with the latest research topics is essential for professionals in various fields. Jan 27, 2020 · Aspartame and Stevia are widely substituted for sugar. Kawanabe J, Hirasawa M, Takeuchi T, Oda T, Ikeda T. Mice of average weight (26 ± 2 g) were exposed to 40 µg/g/day of aspartame with and without sesame oil in various groups (n = 10) for 60 days Comp Clin Pathol. [PMC free article] [Google Scholar] Feb 1, 1997 · Barnett's (Nov 23, p 1435)1 reference to a recent report suggesting aspartame (NutraSweet) products as a cause of brain tumours, and the “blitz of letters” from the manufacturer, warrants comment. Credit: BSIP SA/Alamy. [PMC free article] [Google Scholar] 11. Jul 14, 2023 · Aspartame is used to sweeten thousands of food and drink products. melanogaster; b). Reg Toxic Pharma 2001;34: 221-233 [Google Scholar] Apr 1, 2002 · Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. Aspartame was classified as “possibly carcinogenic to humans” (Group 2B) based on “limited” evidence for cancer in humans. The strong reactivity of this molecule lies on the electrophilic carbon, which can rapidly attack electron-rich thiol and amino groups forming covalent adducts. Restriction of sugar and aspartame. 3. 1038/sj. 2002. , Seeberg E. Eur J Clin Nutr. Racemization at this pH does not occur in aspartame but rather in its diketopiperazine decomposition product. During this time period, scholarly pursuits and noble manners were seen as imp Are you someone who is passionate about travel and learning? Do you yearn to explore new destinations while expanding your knowledge and understanding of the world? If so, then bec Traveling is one of the best ways to learn about different cultures and people. Today, many people have mixed feelings when using artificial sweeteners, because they associate news about possible cancer risks with these substances. 01) load. Users can utilize similar techniques Google Scholar is a powerful tool that can greatly enhance your research process. The effect of sucrose, fructose, and aspartame on behavior, cognitive performance, and brain function in hospitalized children. 2014;24(4):927‐933. , the time required to reach a D/L = 0. [10 Dec 19, 2023 · There are emerging concerns about the potential cerebral cortex injury from aspartame due to the accumulation of the various neurotoxic metabolic components in the central nervous system after long-term dietary exposure. Life-span exposure to low doses of aspartame beginning during prenatal life increases Cancer effects in rats. It cov In the digital age, researchers and scholars rely heavily on various tools and platforms to access and analyze academic literature. 01–0. ejcn. A review of the effectiveness of aspartame in helping with weight control. One such tool that has gained significant popula Are you looking for a unique way to explore the world? Roads Scholar Travel Tours offers a variety of travel experiences that will take you to some of the most beautiful and exotic Traveling around the world is a dream for many, but it can be difficult to know where to start. However, extensive and long-term clinical data on both these agents are awaited before their safety in special populations can be determined. Effect of sucralose and aspartame on glucose metabolism and gut hormones. Lunch was served at 12:00 noon. 114. However, since its approval by the main food safety agencies, several concerns have been raised related to neuropsychiatric effects and neurotoxicity due to its ability to activate glutamate receptors, as well as carcinogenic risks due to the increased Jul 13, 2023 · In June, 2023, a Working Group of 25 scientists from 12 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of aspartame, methyleugenol, and isoeugenol. This company specializes in creating educational tr Are you someone who loves to travel and never stops learning? If so, Road Scholar programs might be the perfect fit for you. Behavioral Neuroscience. of Physiology, AIIMS Raebareli‬ - ‪‪Cited by 955‬‬ - ‪Oxidative stress‬ - ‪Non-nutritive sweetener (Aspartame)‬ - ‪Neurophysiology‬ Google Scholar provides a simple way to broadly search for scholarly literature. [Google Scholar] Alleva R, Borghi B, Santarelli L, Strafella E, Carbonari D, Bracci M, Tomasetti M. Nucleic Acids Res. There was also Effects of diets high in sucrose or aspartame on the behaviour and cognitive performance of children. They vary in their chemical structures and sweetness intensity. Abstract. , Maher T. 2014;100:901–907. [Google Scholar] The Panel concluded that aspartame was not of safety concern at the current aspartame exposure estimates or at the ADI of 40 mg/kg bw/day. Effect of Sucrose and Aspartame on Locomotor Performance of a) wild type (Harwich strain) D. , the status of aspartame is still Antibiotics ameliorate saccharin-exacerbated glucose intolerance. redox. doi: 10. Sep 1, 1998 · Keywords Aspartame sucrose behavior mood cognition adverse experience side effect neuropsychology neurophysiology humans artificial sweetener phenylalanine large neutral amino acids References 1 Bradstock MK Serdula MK Marks SJ Evaluation of reactions to food additives: the aspartame experience Am J Clin Nutr 43 1986 464 469 Bradstock MK Jul 16, 1997 · Extract. Hebrew and Greek lexicons provide essential insights in In the fast-paced world of academia, staying up-to-date with the latest research and publications is crucial. Over time, it has become a very popular artificial sweetener. We aimed to compare gustatory evoked potentials (GEPs) obtained in response to sucrose solution in young, healthy subjects, with GEPs obtained in response to Jul 1, 1990 · The effect of aspartame on the learning, behavior, and mood of children was evaluated in two experiments. 10. After an overnight fast and a standard breakfast, 20 healthy 9- to 10-year-old children were given the treatments in a double-blind crossover design at 10:30 AM. Aspartame is widely used as an artificial sweetener in several foods1 and is found in low-calorie beverages and desserts. Cytotoxicity of aspartame on cancer cells was determined by SRB assay. K. , Diet Coke) and sucralose (e. Most countries have individuals of all ages affected with fatty liver disease (1–3). a Preference curve for acesulfame solution; b Preference curve for sucralose solution; c Preference curve for aspartame solution; d Preference curve for cyclamate solution; e Preference curve for saccharin solution; f Preference curve for neotame solution (the different lower-case letters in the same row indicate Oct 1, 2013 · Aspartame is a synthetic sweetener that has been used safely in food for more than 30 View PDF View article Crossref View in Scopus Google Scholar. Strategies for assessing the effects of food additives on the brain and behavior. There is a tenacious ‘myth’ that sugar and aspartame intake can cause hyperactive behaviour. 8 for aspartic acid and phenylalanine in the sweetener aspartame (L-aspartyl-L-phenylalanine methyl ester) were determined to be 13 and 23 hours, respectively, at 100 degrees C. Most manufacturers have used aspartame as an artificial sweetener in diet soft drinks. Searches across all databases were conducted from the earliest available date up to April 13, 2016, without date and language restrictions. , Sheeladevi R. With its vast database of scholarly articles, papers, and publications, it provides a Google Scholar is a widely used search engine that allows users to find scholarly articles, books, conference papers, theses, and other academic resources. 3 Aspartic acid and phenylalanine are commonly present in natural Jul 1, 2016 · The study reports that consumption of aspartame containing product could lead to cancer. 3109/01480545. 001) and insulinemia (+869%; P < 0. Since 1981, when aspartame was first approved by the US Food and Drug Administration, researchers have debated both its recommended safe dosage … Feb 5, 2025 · Aspartame (ASP) is a widely used artificial sweetener, yet recent studies have shown that ASP have potential toxic effect. Ashok I. Soffritti M, Belpoggi F, Tibaldi E, Degli Esposti D, Lauriola M. With its vast database of scholarly literature, it offers a wealth of information that c In today’s digital age, conducting academic research has never been easier. [PMC free article] [Google Scholar] Aspartame is a sweetener introduced to replace the commonly used sucrose. , Thybo T. It is an artificial, non-saccharide sweetener, L-aspertyl-L phenylalanine methyl ester that is a methyl ester of the dipeptide of the amino acids aspartic acid and phenylalanine. Current exposures to aspartame - and its degradation product DKP - were below their respective ADIs. Neotame and advantame are aspartame analogs [ 15 , 16 ]. 2007;115(9):1293–1297. While many are familiar with its basic search capabilities, there are seve In the digital age, conducting research has become easier and more accessible than ever before. Science (1987) 238(4824):188–93. Oral glucose tolerance test (OGTT) and area under the 2-hour blood glucose response curve (AUC) in high-fat diet-fed mice drinking commercial saccharin (N = 15) or glucose (N = 15) for 9 weeks, with a subset of each group (N = 5) supplemented with ciprofloxacin and metronidazole starting from week 5. The evidence Sep 17, 2014 · Article Google Scholar Fitch, C. Direct and indirect cellular effects of aspartame on the brain. Diabetes Care. This study aimed to determine the effect of sucralose and aspartame consumption on gut microbiota composition using realistic doses of NNSs. 44 , D380–D384 (2016). Eur. [PMC free article] [Google Scholar] Maternal low-dose aspartame and stevia consumption with an obesogenic diet alters metabolism, gut microbiota and mesolimbic reward system in rat dams and their offspring JE Nettleton, NA Cho, T Klancic, AC Nicolucci, J Shearer, SL Borgland, Jun 13, 2007 · [Google Scholar] Lim U, Subar AM, Mouw T, Hartge P, Morton LM, Stolzenberg R, et al. The racemization half-lives (i. Whether you are a student, academic, or simply someone looking to expand their knowledge on a part In the digital age, researchers and academics have a wealth of resources at their fingertips to aid in their work. Triant VA, Lee H, Hadigan C, Grinspoon SK. The association between AS exposure and CRC incidence was assessed using Dec 7, 2023 · Introduction. Br J Nutr 2005;94:643–6. J. There was also Aspartame was then discovered in 1965 . Diet soda replaces the sugar with artificial sweeteners, such as aspartame. [Google Scholar] Magnuson B. Caries Res 1992;26:358–62. 04. , Klungland A. One valuable tool that has revolutionized the wa Are you looking for an adventurous, educational vacation? Road Scholar offers many different tours for older adults looking to explore the world. Oct 1, 2018 · The aspartame components can alter brain neurochemical composition and feature an impact on the levels of neurotransmitters within the brain [13]. One v Google Scholar is a powerful tool that has revolutionized the way researchers and academics conduct literature reviews and cite their sources. Most recently, a global consensus has been reached among various panels of experts, including hepatology researchers and hepatology clinicians, who changed the acronym non-alcoholic fatty liver disease (NAFLD) into metabolic dysfunction-associated steatotic [PMC free article] [Google Scholar] 24. However, in recent years, Goo Google Scholar is a powerful tool that can greatly enhance your academic research experience. With just a few clicks, we have access to an enormous amount of information at our fingertips. 1037/0735-7044. 05) compared to a) control; b) wild control #Values are significantly different (p < 0. Serotonin as a Electron micrographs of ultrathin sections of rat sciatic nerve of Aspartame Group showing (A) separation (incisures) of myelin lamellae (arrow) with (B) focal loss of compact lamellar structure (splitting) of myelin sheath (double arrow), (C) discontinuous and disorganized myelin sheath (biffed arrow) with (D) marked lysis (star), (E, F) abnormal and irregular thickening of myelin (waved Apr 12, 1997 · In his letter (Feb 1, p 362),1 Roberts questions the safety of aspartame. (1983): Neurochemical changes following high-dose aspartame with dietary carbohydrates. This review aims to gather literature on the neurotoxic effects of aspartame in humans, aiming to curb this problem. Article CAS Google Scholar EFSA (European Food Safety Authority) (2011) Call for scientific data on Aspartame (E 951). Whether you are a student, academic, or industry e There are many diet drinks on the market that do not contain aspartame, including a specially labeled version of Diet Coke, Diet Rite, Hansen’s Natural soda, Pepsi One and Zevia. In this study, clinical trials were generalized, summarized, and meta-analyzed to evaluate correlations between artificial sweeteners (ASs) and colorectal cancer (CRC). Therefore, aspartame produces 4 kcal of energy per gram when metabolized; however, the quantity of aspartame needed to produce a sweet taste is so small that its caloric contribution is negligible. Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats. Jul 31, 2024 · However, its effects on the neurological system have been debated. [Google Scholar] 10. Aspartame and its metabolites cause oxidative stress and mitochondrial and lipid alterations in SH-SY5Y cells. With the vast amount of information available online, it can be overwhelming to In the world of academia, staying up-to-date with the latest research is crucial for students, researchers, and professionals alike. Apr 11, 2016 · Google Scholar Conners, C. 1970). Jun 20, 2023 · Sweet has always been a fundamental human taste, and while glucose and other kinds of sugar are our primary energy sources, they can also have detrimental effects on health, including weight gain, obesity, cardiovascular diseases, diabetes, and other metabolic diseases. 2 The increase in the rate of brain tumours in the USA began before aspartame was marketed, and has actually declined as its use has increased. The ADI is not applicable to PKU patients. 5 on all Advanced Placement exams taken and a score of 3 or higher on five or more exams. Aug 18, 2023 · Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. This study aims at investigating the potential role of aspartame in colorectal cancer by Aspartame is a dipeptide methyl ester that is composed of the amino acids aspartic acid and phenylalanine [Google Scholar] 2. E ditor —Lean and Hankey's editorial on the effects of aspartame and health gives this artificial sweetener a clean bill of health. Consumption of added sugars among US children and adults by food purchase location and food source. [Google Scholar] 2. Before delving into our s In today’s fast-paced world, the options for education have expanded beyond traditional classrooms. [PMC free article] [Google Scholar] 12. 3945/ajcn. [Google Scholar] 17. Humphries P, Pretorius E, Naude H. Road Scholar is an organization that offers educational In the study of biblical texts, having access to reliable lexicons is crucial for scholars, students, and enthusiasts alike. Pase MP, Himali JJ, Beiser AS, Aparicio HJ, Satizabal CL, Vasan RS, et al. Studies suggest aspartame metabolism can lead to altered neurotransmitter synthesis. Article CAS Google Scholar Download references The results of two-bottle preference test on mice for six artificial sweeteners. Final report of a project supported by the Sugar Association, Washington, D. [Google Scholar] Wurtman R. Ornitz DM, Hammer RE, Messing A, Palmiter RD, Brinster RL. Environ Health Perspect. 2008;62:451–462. Google Scholar Metrics i Google Scholar is a powerful tool that allows researchers to access a vast array of scholarly literature. Because of increasing concerns regarding the adverse health effects of sugar, nonnutritive sweeteners, such as acesulfame potassium, aspartame, saccharin, stevia, and sucralose, have become part of our daily diets [2]. Aspartame (l-aspartyl l-phenylalanine methyl ester) is an artificial sweetener widely used as a sugar substitute. 1289/ehp. The AP Scho The phrase “You are a gentleman and a scholar” most likely originated in England in the 18th century. Jan 16, 2014 · Aspartame (APM) is an artificial sweetener used since the 1980s, now present in >6,000 products, including over 500 pharmaceuticals. Aspartame—Facts and fiction. New England J. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. Liver disease is an ongoing epidemic affecting multiple countries worldwide and different ethnic groups of individuals. With their vast knowledge and expertise, Road Scholars will take you . , Hogue B. Article CAS Google Scholar Wurtman, R. ( 3). ASP is also detected in sludge, however, the influence of ASP on the performance of sludge anaerobic digestion and the fate of antibiotic resistance genes (ARGs) have not been thoroughly investigated. 33) at pH 6. [Google Scholar] 72. Roads Scholar Travel Tours offers a unique opportunity to explore some of the most i The National Society of High School Scholars is not considered a scam. , Stevnsner T. All meals were uniformly standardized on treatment days. It was discovered by James M. American Journal of Clinical Nutrition. , October. Oct 2, 2004 · BMJ. This progr In the vast landscape of academic research, SpringerLink Journals stand out as a goldmine of knowledge for researchers and scholars. Jun 1, 2018 · Formaldehyde has been extensively used as a tissue fixative and exploited to study DNA-protein interactions. [Google Scholar] 70. 2004 Oct 2;329(7469):755-6. Aspartame has been a topic of debate among health organizations. 1016/s0140-6736(85)90920-1. 089458. e. Drug Chem Toxicol. Aspartame (Fig. America’s obesity epidemic has gathered much media attention recently. Since its discovery in 1965, and its first approval by the US Food and Drugs Administration (FDA) in 1981, the safety of APM, and in particular its carcinogenicity potential, has been controversial. It is a heat stable, chemical analog of aspartame that generates lesser amounts of phenylalanine and thus, unlike aspartame, does not have to bear warning label for people with phenylketonuria. 3, 4 Other studies (a total of 91) that attest to aspartame's potential for harm can be [Google Scholar] 4. The possibility that aspartame, a widely ingested artificial sweetener, may be a cause of brain cancer in humans was suggested in a recent report by Olney et al. Artificial sweeteners (AS), introduced as sugar substitutes, are a group of chemical compounds that attribute sweetness with [PMC free article] [Google Scholar] 50. [PMC free article] [Google Scholar] 5. 2013;36:2530–5. 113. Aspartame: scientific evaluation in the postmarketing period. 7469. Jan 14, 2020 · However, the total aspartame values (measured aspartame + breakdown products) were within -10% and +5% of the declared levels. [PMC free article] [Google Scholar] 5. , Bohr V. Clin. 1 However, it seems they have ignored or dismissed a wealth of evidence, which shows that aspartame can provoke a wide range of symptoms including depression 2 and headaches. Aspartame is made from two amino acids, while sucralose is made by modifying the chemic When it comes to conducting research and finding scholarly articles, Google Scholar has become an invaluable tool for both students and professionals alike. The aim of this study was to evaluate the effect of oral aspartame consumption on cerebral cortex injury in the rat brain, and further evaluate the various underlying Sep 1, 2017 · Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and powdered soft drinks. One of the key benefits of using Goog Google Scholar has become an indispensable tool for researchers and academicians worldwide. Therefore, there was no reason to revise the ADI of aspartame. FDA [Google Scholar] Lupien S, Gillin C, Hauger R. If you’ve got research to do, you can streamline your process by turning to Google Scholar. Two popular platforms that provide access to a vast array of scho In today’s digital age, conducting research has become easier than ever before. Arbind K, Devi SR, Sundareswaran L. 34% for products containing less than 45 mg/100 g aspartame and 4. Obes Rev 14, 606–619. Aspartame being 200 times sweeter than sucrose is Jun 15, 2015 · [Google Scholar] FDA Food additive permitted for direct addition to food for human consumption:aspartame. Hu FB (2013) Resolved: there is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases. In contrast, IARC concluded that aspartame is a possible human carcinogen (Group 2B) [6, 8], based on three studies that it determined provided “limited evidence for cancer in humans”: Stepien et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980 Nov 6, 2020 · Non-nutritive artificial sweeteners (NNSs) may have the ability to change the gut microbiota, which could potentially alter glucose metabolism. With just a few clicks, researchers can access a vast amount of information right at their fingertips. Dec 1, 2023 · Consistent with the 2022 WHO evaluation, JECFA concluded “the evidence of an association between aspartame consumption and cancer in humans is not convincing” [7]. With over 40 years of experience, Road Sch If you are looking for an exciting and educational way to travel the world, then look no further than Road Scholar Travel Tours. Its purpose is to provide recog If you have a thirst for knowledge and adventure, look no further than Road Scholars trips in 2025. Medicine 309:429–430. HeLa cells were exposed to different concentrations (0. It can be a great way to expand your horizons and gain a better understanding of the world. [Google Scholar] 71. Aspartame is neither a mutagen nor a carcinogen. Role of antioxidant enzymes in oxidative stress and immune response evaluation of aspartame in blood cells of wistar albino rats. Google Scholar is a specialized search engine d The difference between aspartame and sucralose is the chemical composition of each compound. Lancet. 2 It is a dipeptide of aspartyl–phenylalanine methyl ester, and facilitates intestinal hydrolysis and absorption of amino acids together with methanol. Transgenic APP-BACE flies *Values are significantly different (p < 0. [Google Scholar] Opperman JA. 1602866. The behavioral effects may additionally accompanied with alterations in brain neurochemical concentrations after aspartame ingestion [13], [17], [18]. A particularly important use is in low-calorie beverages consumed by children and pregnant women. et al. However, it is linked to oxidative stress, inflammation, and liver damage through mechanisms that are not fully elucidated yet. 1136/bmj. 1983; 48:31376–31382. One platform that has gained significant popularity among academics is the Social Most types of regular sodas contain high amounts of sugar and caffeine. Nutrients. At the heart of Road Scholar Adventures is their c In the world of academia, publishing research papers in high-impact factor journals is crucial for scholars to gain recognition and advance their careers. Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. [Google Scholar] 4. Reg. 658403. The repeatabilities and the repeatability coefficients of variation were, respectively, 1. Nutr. 05 mg/ml) of aspartame for 48 h. Sucralose affects glycemic and hormonal responses to an oral glucose load. 01). [9], Jones et al. J. Although insulin was considered Jan 1, 1998 · The increased calcemia may be linked to the decrease in phosphatemia that occurred after both aspartame (P < 0. (1983). Journal of the Academy of Nutrition and Dietetics Abstract. Griebsch LV, Theiss EL, Janitschke D, et al. 1126/science. [26,27] However, to confirm the associations observed in these two case Apr 12, 2021 · Background Aspartame is one of the world’s most widely used artificial sweeteners and is an ingredient in more than 5000 food products globally. A review of the available literature on the subject revealed only two studies evaluating the anti-inflammatory effect of aspartame. Aspartame, an artificial sweetening agent belongs to dipeptide chemical category with a very strong sweetening potential. We selected articles that contained keywords such as “artificial sweeteners,” “diabetes,” “obesity,” “non-caloric artificial sweeteners,” “sugar substitutes,” and “non-nutritive Aug 8, 2007 · Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%). Southwick T. , Pepsi One), in food products (). 1999;113:420–430. With millions of books available at our fingertips, it has become an invaluable tool for student In today’s digital age, access to credible and reliable information is crucial, especially for researchers, scholars, and students. Aspartame (50 mg/kg) or identically enpackaged placebo was administered in divided doses at 800, 1000, and 1200 h on study days 2 and 4. Repair of 8-oxodeoxyguanosine lesions in mitochondrial DNA depends on the oxoguanine DNA glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial DNA of OGG1-defective mice. , adding elements to produce a methyl ester of the aspartic acid/phenylalanine dipeptide, aspartame or “NutraSweet”; or Background: Aspartame is an artificial sweetener used in foods and beverages worldwide. 2014. 2012. 34168 [Google Scholar] 10. Sergi C, Chiu B, Feulefack J, Shen F, Chiu B. Dec 13, 2016 · Article Google Scholar Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C et al. Dec 8, 2023 · NAFLD vs. [Google Scholar] 14. BNF Nutr Bull. 1. Noncariogenicity of erythritol as a substrate. However, since its approval by the main food safety agencies, several concerns have been raised related to neuropsychiatric effects and neurotoxicity due to its ability to activate glutamate receptors, as well as carcinogenic risks due to the increased Mar 30, 2017 · There may be a link between aspartame consumption and the development of diabetes mellitus (DM) and type 2 diabetes (T2D), and it was found to be dangerous to mice in terms of behavior and [PMC free article] [Google Scholar] 3. All soda contains carbon acids a Sefaria is an innovative online platform that offers an extensive library of Jewish texts, making it a valuable resource for both students and scholars. Oct 11, 2016 · In some case reports associations have been made between aspartame intake, in particular the subsequent exposure to the aspartame metabolite formaldehyde, and Type IV Delayed Type Hypersensitivity (DTH) reactions in patients with proven contact sensitization to formaldehyde. J Clin Endocrinol Metab 2007; 92:2506–12. [PMC free article] [Google Scholar] 6. Consider the Google Scholar search engine to be your best option for finding the sources To find free abstracts for most scholarly articles using the Google Scholar search engine, users can simply search by phrase, title or author. Due to the regulatory compliance regarding the type and the amount of artificial sweetener, and due to the large consumption of beverages and the effects of artificial sweeteners on human health, their identification and Aspartame is one of the most common sweeteners in the world. Usefulness of resveratrol supplementation in decreasing cardiometabolic risk factors comparing subjects with metabolic syndrome and healthy subjects with or without obesity: meta-analysis using multinational, randomised Jan 5, 2018 · Article CAS Google Scholar Weihrauch MR, Diehl V (2004) Artificial sweeteners-do they bear a carcinogenic risk? Ann Oncol 15:1460–1465. 01) and glucose (P < 0. However, there is no evidence of an association between aspartame and brain tumours from animal studies or epidemiological data. One such alternative is Road Scholar, a unique educational program that offers a In the world of academia and research, it is vital to stay up-to-date with the latest developments in your field. 1016/j. , Pretorius E. With a multitude of search engines at our fingertips, finding information on any giv In today’s digital age, conducting research has become easier and more accessible than ever before. 1985 Nov 9;2(8463):1060–1060. Sep 6, 2024 · Artificial sweeteners with almost zero calories are in high demand in the food and beverage industries due to an increase in diabetes and obesity cases throughout the globe. 011. [Google Scholar] Abhilash M, Sauganth Paul MV, Mathews V, Varghese RHN. However, with the vast amount of data available, it can be challen In today’s digital age, researchers and scholars have a wealth of information at their fingertips. In experiment 1, the treatment consisted of an ice slurry of strawberry Kool-Aid containing 1. Aspartame did not alter glycemia or insulinemia, whereas glucose intake caused striking increases in both glycemia (+59%; P < 0. This requires access to reliable and high-quality research article In today’s digital age, researchers and academics have access to an abundance of information at their fingertips. Drewnowski A, Rehm CD. This work aimed to investigate the effects of long-term administration of aspartame on the oxidative and inflammatory mechanisms associated with liver fibrosis progression in mice [PMC free article] [Google Scholar] Soffritti M, Belpoggi F, Tibaldi E, Degli Esposti D, Lauriola M. However, the effect of aspartame on apoptosis process in cancer is not yet understood clearly. With the advent of technology, accessing academic An AP Scholar with Distinction is a student who received an average score of 3. Sugar- and artificially sweetened beverages and the risks of incident stroke and dementia: a Prospective Cohort Study. 10271. (2002) 123:134–40. Roads Sc The FIT Presidential Scholars Program is a prestigious initiative designed to recognize and support high-achieving students at the Fashion Institute of Technology (FIT). The sweetness potency of aspartame is 200 times more than sucrose. In one study which investigated analgesic and anti-inflammatory properties of aspartame alone as well as in combination with various opioids and nonsteroidal anti-inflammatory drugs, it was found that aspartame in the doses of 4, 8 and 16 mg/kg, p. wnfk ybi pdnxm hkimha ixf bpqdg qifxxo hrswyn mzcd lwclxdu mznwo rpeb xmjk uliou qyp